Paradigm shift in dosage determination of anticancer agents.

Potential anticancer agents, XI. X-ray structure determination of acantholide.

The X-ray structure of acantholide, a melampolide sesquiterpene lactone from Acanthospermum glabratum (DC.) Willd. was determined by the aid of direct methods. The compound was cytotoxic but displayed no antitumor activity. Evaluation of the X-ray and NMR data indicated that the same conformation exists in the solid state as in solution.

Paradigm Shift

A paradigm shift, suggested by Thomas Kuhn [1], is not just a small change in science, or the modification of a theory. It is a scientific revolution and completely changes the way in which science looks at the world. It often dictates how the public looks at the world. For example, Darwin's theories [2] were intensely debated by scientists and theologians. This debate spilled over into the pub...

paradigm shift of health towards obesity in childhood

A Methodology for Paradigm Shift to Explain Sustainable University

The sustainable university concept is rooted in prevalent paradigms pertained to economic, social and environmental development, which all focus on systemic thought and rationality; besides, they tend to  discover and solve problems by applying an interdisciplinary approach. However, the epistemic component is what these paradigms have ignored. The purpose of this study is to explain a methodo...

determination of maximal singularity free zones in the workspace of parallel manipulator

due to the limiting workspace of parallel manipulator and regarding to finding the trajectory planning of singularity free at workspace is difficult, so finding a best solution that can develop a technique to determine the singularity-free zones in the workspace of parallel manipulators is highly important. in this thesis a simple and new technique are presented to determine the maximal singula...